An open-access portal tracking research advances and datasets across Alzheimer’s disease, Parkinson’s disease, and ALS. Aggregating scientific findings and open repositories from Alzforum, bioRxiv, OpenNeuro, DANDI, and Agora.
Spatially resolved RNA imaging combined with sequencing maps cellular crosstalk across hippocampal subregions.
Subcellular MERFISH and single-nucleus RNA sequencing across human post-mortem white matter lesions map complement C1q signaling and interferon-responsive oligodendrocyte states at paramagnetic lesion rims.
Prospective multi-center validation across 1,420 MS patients demonstrating that elevated serum GFAP paired with paramagnetic rim lesions (PRLs) predicts 24-week confirmed PIRA independent of acute gadolinium-enhancing relapses.
A 24-month longitudinal cohort of 650 Parkinson’s patients monitored with wrist-worn IMU accelerometer arrays establishes automated machine learning scores correlating with MDS-UPDRS Part III subscores.
Preclinical evaluation of novel mTORC1 inhibitors in neurodegenerative models demonstrating reduced neuroinflammation.
Persistent fear is a central feature of anxiety, but it remains unclear whether this persistence is more closely related to the consistency of conditioned-threat processing or to the consistency of subjectively experienced fear. Using a longitudinal naturalistic viewing fMRI paradigm, we examined wh...
The present study aimed to directly replicate the seminal findings of Decety et al. (1989), while also extending the original work with a larger sample size and additional statistical analyses. Thirty healthy adults completed both imagined and executed walking tasks over distances of 5, 10, and 15 m...
Plants from distantly related lineages can produce identical neuroactive molecules, many of which have been independently adopted across human societies for their medicinal and cognition-altering effects. This phenomenon is exemplified by the traditional use of Syrian rue (Peganum harmala) and the a...
Pursuit of reward drives many aspects of daily life and can be altered in several psychiatric disorders including depression. Reward seeking impairments in depression are reportedly poorly managed by the typical frontline therapeutics, selective serotonin reuptake inhibitors (SSRIs), suggesting that...
Precision psychiatry research has strived to characterize the neural circuitry underlying transdiagnostic symptoms with the goal of devising biologically informed diagnostic and treatment strategies. However, few clinically actionable findings have emerged from these initiatives. One potential compl...
Brain-state-guided and closed-loop transcranial magnetic stimulation (TMS) protocols have emerged as methods for decreasing the outcome variability and increasing the therapeutic effectiveness of stimulation protocols. However, existing brain-state-dependent TMS systems control only stimulation timi...
Systematic prioritization of candidate Alzheimer's disease (AD) genes and their target functions for therapeutic intervention requires a consistent understanding of their brain location, cell-type-specific expression, relationships with pathology, and direction of change. Defining the role of a gene...
This portal tracks and synchronizes open CNS data based on the following criteria: