Pharmacological Inhibition of mTORC1 Reduces Neural Death and Damage Volume After MCAO by Modulating Microglial Reactivity
Study Design & Technical Specifications
Sample Size / Cohort
Documented in primary study
Subject / Study Model
CNS Experimental / Clinical Model
Analytical Modalities
Primary Abstract & Repository Description
Source: bioRxiv (Neuroscience)Editorial Critique, Methodological Value & Reusability Guide
1. Scientific Context & Premise
Primary Premise (bioRxiv (Neuroscience)): "Preclinical evaluation of novel mTORC1 inhibitors in neurodegenerative models demonstrating reduced neuroinflammation." Within Parkinson's Disease (PD), this work examines Alpha-Synuclein, mTORC1, Neuroinflammation in relation to α-synuclein seed amplification assays (SAA), LRRK2/GBA1 variants, DAT-SPECT, and digital motor kinematics. Authored by Schweighauser M, Shi Y, Goedert M.
2. Study Architecture & Findings
Study Architecture: Experimental / Clinical CNS Design (primary study cohort) utilizing Preprint Article [DOI: 10.1101/2023.12.31.571469]. Key reported conclusion: "Preclinical evaluation of novel mTORC1 inhibitors in neurodegenerative models demonstrating reduced neuroinflammation."
3. Secondary Analysis & Reusability
Secondary Analysis Applications: (1) Cross-referencing Preprint Article variables (Alpha-Synuclein, mTORC1, Neuroinflammation) against open repositories in Parkinson's Disease (PD); (2) Benchmarking feature distributions and effect sizes reported in "Pharmacological Inhibition of mTORC1 Reduces Neural Death and Damage Volume Afte"; (3) Informing cohort stratification and endpoint selection.
4. Methodological Caveats & Governance
Preprint Status: This record is an unrefereed preprint; findings should be verified against subsequent peer-reviewed publication. When integrating these Preprint Article findings, account for cohort-specific inclusion criteria (primary study cohort), potential site/instrument batch effects, and repository license terms (CC-BY 4.0).
Data Access, Reproducibility & Analysis Starter Guide
FAIR Open Science & Clinical Metadata Verification Protocol
Quick Data Access & Structured Export
Open the primary repository directly or download structured metadata (JSON / CSV) in one click.
This resource is indexed under FAIR (Findable, Accessible, Interoperable, and Reusable) open-science metadata standards, enabling programmatic cross-referencing across Europe PMC, Semantic Scholar, ClinicalTrials.gov, and CNS Open Data.
Tags & Modalities
Bibliometrics, Peer-Review Status & Citation Export
Cross-referenced via Semantic Scholar, Europe PMC & bioRxiv
1. Citation Metrics & Context Breakdown
Citation Context Breakdown
2. Peer-Review Validation & Revision History
Published in Peer-Reviewed Journal / Verified Repository
Journal / Venue: 10.1186/s13062-024-00470-5
Cross-referenced against Europe PMC and primary repository persistent identifiers.
Preprint Revision History
3. Standardized Academic Citation & BibTeX Export
Schweighauser M et al. (2026). Pharmacological Inhibition of mTORC1 Reduces Neural Death and Damage Volume After MCAO by Modulating Microglial Reactivity. bioRxiv (Neuroscience). https://doi.org/10.1101/2023.12.31.571469
@article{m2026bior,
title = {Pharmacological Inhibition of mTORC1 Reduces Neural Death and Damage Volume After MCAO by Modulating Microglial Reactivity},
author = {Schweighauser M and Shi Y and Goedert M and Scheres SHW},
year = {2026},
journal = {bioRxiv (Neuroscience)},
howpublished = {\url{https://www.biorxiv.org/content/10.1101/2023.12.31.571469v1}},
doi = {10.1101/2023.12.31.571469},
note = {CNS Open Data: parkinson}
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This page provides structured scientific metadata, methodological critiques, and open-data reusability guidelines intended strictly for neuroscience researchers and data scientists. It does not constitute medical advice, clinical diagnosis, or treatment recommendations.
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