Full raw neuroimaging repository containing 3T T1w, T2w, Diffusion-weighted MRI (dMRI), Resting-State fMRI, and [18F]Florbetapir Amyloid-PET scans from 180 subjects formatted strictly to BIDS standard.
Task-based and resting-state 3T fMRI dataset examining levodopa ON vs OFF states in 72 Parkinsonian individuals and age-matched controls, complete with behavioral logs.
Over 1,200 human surgical neocortical pyramidal neurons and interneurons characterized simultaneously with patch-clamp electrophysiology, fluorescent morphological reconstruction, and single-cell RNA sequencing in NWB 2.0 format.
High-density intraoperative and chronically implanted deep brain stimulation (DBS) electrode recordings during motor resting and movement states from 34 patients with idiopathic PD.
Electrophysiology (LFP)Kinematics#DBS#Local Field Potential#Beta Oscillations#Subthalamic NucleusCohort: 34 Patients
Comprehensive multi-omic profile of INPP5D incorporating RNA-seq across 7 brain regions (ROSMAP, Mayo, Mount Sinai cohorts), proteomics expression changes, and mouse model phenotypic validation data.
Integrated evidence demonstrating significant downregulation of VGF in temporal cortex and precuneus in severe AD, correlated with rapid cognitive decline and synaptic loss.
Landmark observational dataset containing longitudinal data from de novo Parkinson’s patients, prodromal individuals with REM sleep behavior disorder (RBD) or hyposmia, and genetic mutation carriers (LRRK2, GBA). Includes CSF α-synuclein Seed Amplification Assay (SAA) validation.
High-resolution cell atlas spanning more than 3 million single nuclei across 100+ human brain regions, mapping distinct vulnerable neuronal and glial sublineages implicated in neuropsychiatric and neurodegenerative conditions.
10x snRNA-seqMERFISHSpatial Epigenomics#Allen Brain Map#BICCN#scRNA-seq#Cell AtlasCohort: 3.2 Million Nuclei