Central Nervous System Open Data Portal

Distinguishing resident microglia from engrafted peripheral myeloid cells is important for interpreting CNS inflammation. P2RY12, TMEM119, and FCRLS are widely used to identify microglia, but their ability to distinguish cellular origin after prolonged engraftment remains context dependent. Using bo...

Precision medicine approaches require physiological effects to be informative when translated to the individual. Reliable group differences may have limited individual value when distributions overlap, mechanisms are heterogeneous, or patients differ in phenotype. A feature can differ between group ...

Learning to stabilize an unstable object may depend not only on the accuracy of active corrective interventions but also on when to suspend intervention and allow the object's intrinsic dynamics to evolve. We investigated learning-related changes in control dynamics and associated beta-band electroe...

The human claustrum is a small, irregular, and complexly positioned structure, yet it carries long range projections to most cortical regions responsible for executive functioning. Prior structural MRI research has largely relied on global volume as the metric of its morphology. Such measures may ob...

Figure-ground discrimination via relative motion represents a highly conserved visual computation essential for uncovering camouflage \citep{reichardt1983figure,Egelhaaf1985}. Over forty years ago, the Reichardt-Poggio-Hausen (RPH) model proposed a circuit architecture to explain this phenomenon, re...

Accurate neuronavigation depends not only on the technical performance of the tracking system but also on the reproducibility with which anatomical landmarks are physically localized. We quantified operator- and landmark-specific variability in repeated facial and cranial landmark localization in 19...

Persistent fear is a central feature of anxiety, but it remains unclear whether this persistence is more closely related to the consistency of conditioned-threat processing or to the consistency of subjectively experienced fear. Using a longitudinal naturalistic viewing fMRI paradigm, we examined wh...

The present study aimed to directly replicate the seminal findings of Decety et al. (1989), while also extending the original work with a larger sample size and additional statistical analyses. Thirty healthy adults completed both imagined and executed walking tasks over distances of 5, 10, and 15 m...

Precision psychiatry research has strived to characterize the neural circuitry underlying transdiagnostic symptoms with the goal of devising biologically informed diagnostic and treatment strategies. However, few clinically actionable findings have emerged from these initiatives. One potential compl...

The subthalamic nucleus (STN) is classically associated with motor control but is increasingly recognised as a key component of the neural circuits underlying cognition. However, how the STN encodes learned reward associations and updates these representations when environmental contingencies change...

Auditory perception emerges from the continuous integration of incoming acoustic signals with statistical predictions, a process complemented by simpler local adaptation. Yet, how all these concurrent mechanisms unfold in time remains underexplored. Using magnetoencephalography (MEG) in participants...

In the developing brain, neural circuits are elaborated by the activity-dependent rewiring of synaptic connections. Our earlier self-organization model, which was built on the assumption that axon terminals compete with each other to form synaptic contacts to single dendritic spines, successfully re...